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Scientist / Sr. - Synthetic and Medicinal Chemistry (SF Bay Area)



South San Francisco, CA, USA
Posted on Thursday, January 4, 2024

Vilya is a computational biotechnology company creating a novel class of medicines to precisely target disease biology. We believe computational approaches are an integral, if not foundational, component of drug discovery and development. Our platform is built on ground-breaking research in advanced computational approaches and taps into uncharted chemical space to design new molecular structures not found in nature.

Our molecules open the door to a brand-new class of medicine with enhanced drug-like properties. We are harnessing the power of our platform to go after previously impossible targets in an array of indications. Vilya’s ultimate goal is to solve some of the most challenging unmet medical needs that exist today.

Our Vision: Harness a revolution in technology and biology to better human health

Our Mission: Build an independent, leading biotech company founded on intelligent drug design to cure the incurable

We are seeking a highly-skilled and enthusiastic Scientist or Senior Scientist to join Vilya’s Chemistry team in South San Francisco. This full-time onsite position will play a key role in expanding our platform technology and advancing orally available macrocycles into the clinic.


  • Design, synthesis, purification and characterization of high value building blocks, intermediates, and macrocycles
  • Evaluation and implementation of state of the art synthetic methodologies for the design and synthesis of novel chemical structures
  • Optimization of chemical matter for key parameters including solubility, permeability, potency, stability, and pharmacokinetics
  • Advancement of discovery projects through effective collaboration and communication with all members of the Vilya team
  • May assist with management of CROs
  • May have the opportunity to manage one or more direct reports
  • Provide regular progress updates to the chemistry and cross-functional research teams
  • Effective written communication as required for patent filings, company reports and scientific publications
  • Maintain an accurate and detailed electronic lab notebook
  • Adherence to all safety and environmental regulations


  • PhD in organic or medicinal chemistry
  • 0-10 years post-PhD experience in an academic, biotechnology, or pharmaceutical setting
  • Expertise in the synthesis, purification, and characterization of complex organic small molecules including methodology development and reaction optimization
  • Experience with solution- and/or solid-phase peptide synthesis is preferred
  • Enthusiastic and self-motivated with strong time management and multitasking skills
  • Impeccable scientific integrity
  • Scientifically curious and eager to learn
  • Positive attitude and willingness to do whatever is needed to meet deliverables and advance projects
  • Desire to help build a high-functioning, collaborative chemistry team


  • Opportunity to work in a disruptive startup with a talented, experienced, and growing team of dedicated individuals
  • 401(k) plan with employer matching for contributions
  • Stock options
  • Excellent medical, dental, and vision coverage
  • Open, flexible vacation policy
  • Support to attend professional conferences that are meaningful to your career growth
  • Monthly cell phone stipend
  • Commuter benefits
  • Salary Range: level depending on experience
    • $110,000- $130,000 (Scientist)
    • Sr. Scientist$130,000 - $160,000