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Associate Director, Program Management

Pliant Therapeutics

Pliant Therapeutics

South San Francisco, CA, USA
Posted on Thursday, December 21, 2023

Pliant Therapeutics is a late-stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar to meet the unmet medical needs of physicians, patients and families impacted by fibrotic diseases. As the leader in the discovery and development of novel therapeutics for the treatment of fibrotic diseases, Pliant is developing small molecule drug candidates specifically designed to impact the fibrotic process.

The Company’s lead product candidate, bexotegrast (PLN-74809), is an oral small molecule, selective inhibitor of the αvβ1 and αvβ6 integrins that play a key role in multiple fibrotic pathways. Bexotegrast has received Fast Track Designation and Orphan Drug Designation from the U.S. Food and Drug Administration for both idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC) and Orphan Drug Designation from the European Medicines Agency in IPF and PSC. Pliant is currently conducting BEACON-IPF, a Phase 2b trial of bexotegrast for the treatment of IPF and INTEGRIS-PSC, a Phase 2a trial of bexotegrast for the treatment of PSC.

Pliant has also developed PLN-1474, a small molecule, selective inhibitor of αvß1 for the treatment of nonalcoholic steatohepatitis, or NASH with liver fibrosis. Pliant is conducting a Phase 1 study for its third clinical program, PLN-101095, a small molecule, dual-selective inhibitor of αvß8 and αvß1 integrins, that is being developed for the treatment of solid tumors. The Company also has discovery and development programs in oncology and muscular dystrophies.


The Associate Director, Program Management is accountable for the day-to-day operations of the Global Program Team (GPT) and Clinical Core Team (CCT) focused on the development of Pliant’s lead asset PLN-74809 in IPF. This position will partner with the Global Program Team Leader (GPTL) as the project management lead on this program.

As a member of the Portfolio and Program Management (PPM) organization, this position is also accountable for supporting goals and objectives at the enterprise and departmental levels and may lead initiatives supporting them.


  • Drives high performing Global Program Team (GPT) and Clinical Core Team (CCT), supporting the development of PLN-74809 in IPF. Responsible for team meeting operations.
  • Responsible for maintaining and ensuring team execution of the integrated development plan.
  • Supports the GPTL to develop the program strategy and drive strategic priorities through the GPT.
  • Partners with the CCT leader to drive the design and delivery of the clinical development plan in alignment with the program strategy through the CCT.
  • Owns all IPF program reports and project management tools and processes (e.g., decision calendar, program goals development & tracking, risk register, decisions & actions log, agendas, minutes, budgets).
  • Responsible for timelines, risk management plans, and communication plans.
  • Through the GPT, drives the preparation of Development Review Committee (DRC) presentations (i.e., program strategy endorsement, stage-gate approval, budget approval) and other senior leadership presentations focused on IPF program.
  • Generate critical path/gap analyses and support scenario planning.
  • Works independently within a matrix environment, lead team members, and influence stakeholders.
  • Identifies and implements project management best practices for the broader PPM organization.
  • May support operating model and governance operations.


To perform this job successfully, an individual must be able to perform each essential duty. The requirements listed below are representative of the knowledge, skill, abilities and prior experience required.

  • Advanced Degree (Ph.D., M.D., Pharm.D., MBA) with at least 6 years of pharmaceutical/biotech industry experience, or BA/BS with at least 8 years of pharmaceutical industry experience is required.
  • Experience in a program management/project management role as part of a research-driven pharmaceutical company is required.
  • Experience in late-stage drug development is required.
  • Experience in late-stage regulatory filings is preferred.
  • Experience in cross-functional teams, driving tactical delivery of programs is required.
  • Experience in negotiation and conflict resolution skills, including the ability to influence without reporting authority are required.
  • Outstanding communication skills are required.
  • Experience with drug development in rare disease and/or fibrosis is preferred.

Pliant requires all new hires to be fully vaccinated prior to the first date of employment (subject to any legally required exemptions).

The annual base salary for this role is $180,000 - $190,000. Individual pay may vary based on additional factors, including, and without limitation job-related skills, experience, work location and relevant education or training. Pliant’s compensation package also includes benefits, equity, and annual target bonus for fulltime positions.

To understand how Pliant complies with and manages your personal information with respect to the California Consumer Privacy Act, please visit